CompletedNot Applicable

Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery

Syria78 participantsStarted 2023-03-01

Plain-language summary

Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups. The first is an intravenous injection of dexmedetomidine at a rate of 0.4 micrograms/kg/hour as a continuous intravenous infusion. The second group, the placebo group, injected the second with a normal saline solution, an infusion that will pass through the vein, using blinded, unmarked syringes. Three arterial blood gas (ABG) samples were taken during surgery at designated times. Circulatory PaO2 values were recorded and the Qs/Qt shunt value was calculated.

Who can participate

Age range4 Years – 6 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * children with American Society of Anesthesiologists (ASA) grade III * FEV1/FVC values less than 80% . FEV1/FVC ratio represents the proportion of the total vital capacity that can be exhaled in the first second of forced expiration, whereas FEV1 indicates "Force Expiratory Volume in 1 second" and FVC indicates "Forced Vital Capacity". * Qs/Qt ratio greater than 10 . Exclusion Criteria: * renal failure. * hepatic dysfunction. * congenital and valvular cardiac disease. * neurological illnesses. * During surgery, individuals who did not achieve complete lung isolation were excluded. * During surgery, individuals with poor oxygen saturation (SO2 \<90%) who did not react to maneuvers and anesthetic procedures to boost saturation were removed. * During surgery, Participants who had a heart rate of less than 80 beats per minute, did not react to atropine, or required a dosage of inotropic drugs (dopamine) were also removed from the trial.

What they're measuring

Change in the PaO2

Timeframe: four time points: (T1) 10 minutes after initiation of total lung ventilation (TLV), (T2) 10 minutes after initiation of one-lung ventilation (OLV), (T3) 60 minutes after initiation of OLV, and (T4) 20 minutes after the end of OLV.

Change in the Qs/Qt

Trial details

NCT IDNCT06505772

SponsorDamascus University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-01

View on ClinicalTrials.gov More One-Lung Ventilation trials