nCLE-Cone-beam CT Navigation Bronchoscopy

Inclusion Criteria: * 18 years or older * Suspected pulmonary nodule with an indication for CBCT-NB (decided by multidisciplinary tumour board) * Nodule must be solid or partially solid * Solid part of the nodule must be at least 8 mm * Largest dimension of the nodule on CT equal or less than 30 mm * Ability to understand and willingness to sign a written informed consent Exclusion Criteria: * Inability or non-willingness to provide informed consent * Patients with an endobronchial visible lung tumor on bronchoscopic inspection * Patients in which the target lesion is within reach of the linear EBUS scope * Lung nodules that resolved at the time of index intraprocedural CBCT * Failure to comply with the study protocol * Patients with known allergy for fluorescein or risk factors for an allergic reaction * Pregnant or breastfeeding women * Patients with hemodynamic instability * Patients with refractory hypoxemia * Patients with a therapeutic anticoagulant that cannot be held for an appropriate in-terval before the procedure * Patients who are unable to tolerate general anesthesia according to the anesthesiologist * Patient undergoing chemotherapy as several chemotherapies have fluorescent properties at the same wavelength (e.g. doxorubicin)