The purpose of this translational bench-to-bedside study is to examine the neurobiological effects of an evidence-based technology-delivered mindfulness training (MT) program on vaping-related rsFC alterations in hippocampal networks and testing whether changes in rsFC ((Delta)rsFC) in these networks predict reduction in tobacco vaping behaviors in adolescents. The study also aims to test the accessibility and feasibility of using this mindfulness-based stress reduction (MBSR) platform as an implementation for widespread MT in adolescents.
Who can participate
Age range
13 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. For adolescents aged 17 and under, parental/guardian informed consent to participate in the study
. English language fluency
. Males and females; Age 13-18 enrolled in grades 9-12, or the summer after graduation.
. No MRI contraindications
. No evidence of current psychosis, mania, or significant suicidality
. If on medication for depression, anxiety or ADHD, dose has been stable for 3 months
. No DSM-5 diagnosis of moderate or severe substance use disorder (SUD) related to a psychoactive substance, including tobacco, in the past year
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Brain Connectivity Network
Timeframe: Baseline (pre MBSR training) and post-MBSR training (1-6 weeks after MBSR training)
. Access to necessary resources for participating in a technology-based intervention, which includes smartphone ownership for this study
Exclusion criteria
. Chronic medical conditions associated with cerebral blood flow abnormalities per PI/MAI determination after review of the medical history.
. Neurological conditions that may interfere with MRI data quality per PI/MAI determination after review of the medical history.
. Neurodevelopmental disorders that are likely to significantly affect data in the judgment of the MAI/PI
. Non-penetrating traumatic brain injury with loss of consciousness \> 30 minutes or significant sequelae persisting longer than two weeks or any penetrating traumatic brain injury.
. Changing dose of psychotropic medication in past three months
. Current regular meditation or yoga practice averaging \>10 min/day for \>2 days per week
. Pregnancy, self-report upon protocol entry, but by urine test prior to MRI scan.