The purpose of this translational bench-to-bedside study is to examine the neurobiological effects of an evidence-based technology-delivered mindfulness training (MT) program on vaping-related rsFC alterations in hippocampal networks and testing whether changes in rsFC ((Delta)rsFC) in these networks predict reduction in tobacco vaping behaviors in adolescents. The study also aims to test the accessibility and feasibility of using this mindfulness-based stress reduction (MBSR) platform as an implementation for widespread MT in adolescents.
Who can participate
Age range13 Years – 18 Years
SexALL
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Inclusion criteria
✓. For adolescents aged 17 and under, parental/guardian informed consent to participate in the study
✓. English language fluency
✓. Males and females; Age 13-18 enrolled in grades 9-12, or the summer after graduation.
✓. No MRI contraindications
✓. No evidence of current psychosis, mania, or significant suicidality
✓. If on medication for depression, anxiety or ADHD, dose has been stable for 3 months
✓. No DSM-5 diagnosis of moderate or severe substance use disorder (SUD) related to a psychoactive substance, including tobacco, in the past year
✓. Access to necessary resources for participating in a technology-based intervention, which includes smartphone ownership for this study
Exclusion criteria
✕. Chronic medical conditions associated with cerebral blood flow abnormalities per PI/MAI determination after review of the medical history.
What they're measuring
1
Change in Brain Connectivity Network
Timeframe: Baseline (pre MBSR training) and post-MBSR training (1-6 weeks after MBSR training)
✕. Neurological conditions that may interfere with MRI data quality per PI/MAI determination after review of the medical history.
✕. Neurodevelopmental disorders that are likely to significantly affect data in the judgment of the MAI/PI
✕. Non-penetrating traumatic brain injury with loss of consciousness \> 30 minutes or significant sequelae persisting longer than two weeks or any penetrating traumatic brain injury.
✕. Changing dose of psychotropic medication in past three months
✕. Current regular meditation or yoga practice averaging \>10 min/day for \>2 days per week
✕. Pregnancy, self-report upon protocol entry, but by urine test prior to MRI scan.