Second Ovulation Induction (NCT06502665) | Clinical Trial Compass
CompletedNot Applicable
Second Ovulation Induction
Canada87 participantsStarted 2024-07-04
Plain-language summary
Studies reported various risk factors for inadequate ovulation induction such as body mass index, low ovarian reserve, low baseline FSH and LH, and previous use of contraception or agonist.
The flexibility to use human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone agonist (GnRHa) in ovulation induction for antagonist protocol or progestin primed ovarian stimulation (PPOS) is an advantage helping fertility doctors to decrease the risk of ovarian hyperstimulation syndrome. However, luteinizing hormone (LH) levels \<15UI/L and progesterone ≤11.13nmol/L eight to twelve hours post GnRHa trigger were highly correlated to failed oocyte pickup (FOP).
Rescue hCG have been found to increase favorable outcomes in patients with FOP. The presence of false FOP could be due pharmaceutical reasons and human error. Genuine FOP could be due to intrinsic ovarian pathology.
The FOP is defined as the absence of oocytes after ovarian stimulation and follicular aspiration. It is an uncomfortable situation for the patient and medical team to deal with due to the apparent expectations of favorable results.
Ovulation induction could be via GnRHa, HCG, or both in antagonist protocol and PPOS protocol. Long or short agonist protocol could be triggered only via HCG.
Who can participate
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants with no oocytes retrieved in the first ovum pick-up
Exclusion Criteria:
* Error in trigger medication or timing by the patient/ medical team
* Major absence of information (primary objective, trigger medication, time interval of trigger and ovum pick-up
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at a second ovulation induction during IVF — could doing a second round of stimulation in the same cycle be relevant to my situation, and is that something my clinic offers?
2Since the trial has already completed and was measuring how many eggs were retrieved, has my doctor seen the results, and what do those findings suggest about whether a second stimulation attempt could improve egg yield for someone in my circumstances?
3How does my own egg reserve and response to stimulation compare to the kind of patients who would have been included in a study like this, and would that affect whether a second induction might help me?
4Are there any additional risks — such as ovarian hyperstimulation or hormonal side effects — that come with triggering ovulation a second time in one cycle that I should weigh against the potential benefit of more eggs?
5Before considering an approach like this, should I try a standard single stimulation cycle first, or does my doctor think there's a reason to discuss a two-stimulation strategy earlier in my treatment?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.