Active — Not RecruitingNot Applicable

Biomarkers in Parkinsonian Syndromes

Greece200 participantsStarted 2022-03-23

Plain-language summary

This is a prospective observational study to identify biomarkers in parkinson syndromes. Patients with parkinsonian syndromes at the early stages of disease will be recruited and will be followed up until their established clinical diagnosis or for at least 5 years. In this population, imaging and wet biomarkers as well as clinical data will b systematically collected.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

IΙnclusion Criteria: * Written informed consent, including consent to monitoring * Patients with Parkinsonism and disease duration \< 2 years * Patients with Parkinsonism and disease duration \> 2 years * Healthy individuals without any neurological disease Exclusion Criteria: * Drug-induced parkinsonism (eg, neuroleptics, lithium, valproic acid, metoclopramide). * Metabolic conditions related parkinsonism (eg, Wilson's disease, hypoparathyroidism). * Structural lesions on brain magnetic resonance imaging (MRI) that explain the symptoms, such as normal pressure hydrocephalus, moderate to severe chronic vascular encephalopathy, cerebral infarction, neoplasm * Other serious diseases that indicate a life expectancy of \<5 years. * Active participation in other interventional clinical studies

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Since this study is collecting blood samples to look at DNA and biomarkers like exosomes, could participating give us any early insight into my specific diagnosis — or is the data purely for research purposes with no direct feedback to me?
2This trial covers several different conditions including Parkinson's disease, PSP, and MSA — given that my diagnosis is still being confirmed, could my doctor explain whether being enrolled under one condition label might affect how my case is evaluated if my diagnosis changes later?
3The study is no longer actively recruiting new participants — is there any chance my doctor could still get me enrolled, or are there similar biomarker studies that are currently open that might offer the same kind of detailed workup?
4The trial uses a lot of imaging like PET scans, DaTScan, and MRI alongside clinical rating scales — if I were involved, how much time and travel would all of those assessments realistically require, and would any of those scans or results be shared with my care team?
5Since this is listed as Phase NA — meaning it's an observational study rather than a treatment trial — should I also be asking about separate clinical trials that are actually testing medications or therapies, so I'm not missing out on a potential treatment option?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Demographics

Timeframe: At enrolment

Family history

Timeframe: At enrolment

Age

Timeframe: At enrolment

Disease duration

Timeframe: At enrolment

First motor symptom

Timeframe: At enrolment

First non-motor symptom

Timeframe: At enrolment

Side of onset

Timeframe: At enrolment

Staging

Timeframe: At enrolment and every six months over 5 years

Trial details

NCT IDNCT06501469

SponsorNon-profit organization for scientific research in Parkinson's disease and related disorders

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2031-05-13

View on ClinicalTrials.gov More Parkinson Disease trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Demographics

Timeframe: At enrolment

Family history

Timeframe: At enrolment

Age

Timeframe: At enrolment

Disease duration

Timeframe: At enrolment

First motor symptom

Timeframe: At enrolment

First non-motor symptom

Timeframe: At enrolment

Side of onset

Timeframe: At enrolment

Staging

Timeframe: At enrolment and every six months over 5 years