CompletedNot Applicable

Determining the Dose Response Profile of the Headward Fluid Shift During Varying Gravity Levels

United States9 participantsStarted 2022-07-21

Plain-language summary

Parabolic flight provides a unique opportunity to evaluate the acute changes associated with varying levels of gravity and to describe how key venous parameters change at levels less than normal Earth gravity. Characterizing these changes in response to varying G-levels is an important step in determining what G-level may be required to reverse weightlessness-induced fluid shifts and thus serve as a viable countermeasure during long-duration spaceflight. Further, these results will inform National Aeronautics and Space Administration (NASA) whether there might be a lower risk of Spaceflight Associated Neuro-ocular Syndrome (SANS) and Venous Thromboembolism (VTE) during extended stays on the Moon and Mars.

Who can participate

Age range25 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * In coordination with the parabolic flight company, Novespace, healthy volunteers from the population that are 25-55 years old without a history cardiovascular disease will be recruited for this study. In order to participate, subjects must be able to follow instructions in English. * Participants must be age 18 years or older, hold a French or European Health Insurance Card, and provide medical certification of fitness for flight to NOVESPACE (i.e., NOVESPACE Parabolic Flight Medical Aptitude Certificate) completed by their medical doctor or an Authorized Medical Examiner. * Participants must meet medical criteria and provide certification of fitness for flight to NOVESPACE (i.e. NOVESPACE Parabolic Flight Medical Aptitude Certificate) completed by their medical doctor or an Authorized Medical Examiner. Exclusion Criteria: * NOVESPACE exclusion criteria includes: * Those with certain heart and lung conditions * dizziness * certain inner ear conditions * severe motor disability or impaired bone density * psychosis * mental disability prohibiting emergency evacuation * epilepsy * certain neurological diseases * fear of heights/flying * debilitating anxiety and panic attacks * claustrophobia, women who are pregnant * certain gastrointestinal conditions * those taking certain medications are ineligible to participate * An individual's overall medical fitness for flight is assessed and certified by a medical doctor or Authorized Medical Examiner. * Pregnan…

What they're measuring

Bilateral Internal jugular vein blood flow characterization

Timeframe: 2-3 hours

Bilateral Internal jugular vein pressure

Timeframe: 2-3 hours

Bilateral Internal jugular vein area

Timeframe: 2-3 hours

Trial details

NCT IDNCT06500338

SponsorNational Aeronautics and Space Administration (NASA)

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2023-06-15

View on ClinicalTrials.gov More Healthy trials

Plain-language summary

Who can participate

Age range25 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.