Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition. The exact pathophysiological mechanism of septic acute kidney injury remains a challenge. One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells. The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury. And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Determination of serum expression of pentraxin 3 (PTX3) and uromodulin
Timeframe: 4 days
Determination of expression and 4 days course investigation of miRNAs
Timeframe: 4 days
Target genes of miRNAs and their association with endothelial dysfunction and mitochondrial injury in sepsis
Timeframe: 4 days