Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With … (NCT06495138) | Clinical Trial Compass
RecruitingNot Applicable
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
United States138 participantsStarted 2025-04-21
Plain-language summary
The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis.
Who can participate
Age range
18 Years – 89 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Neurologist-confirmed diagnosis of primary progressive or relapsing and remitting MS per The 2017 Revision of the McDonald Criteria and the Magnetic Resonance Imaging in MS, or a healthy volunteer without a diagnosis of multiple sclerosis or any related neurological conditions
* Fluent in speaking and understanding English
* Subjects with multiple sclerosis have self-reported vestibular symptoms of dizziness, imbalance, and/or a history of at least two falls in the prior 12 months
Exclusion Criteria:
* Clinically isolated syndrome or radiologically isolated syndrome.
* Worsening MS symptoms during the prior 60 days
* Immunotherapy change in the prior 60 days
* Self-reported cognitive impairment that limits independence with basic and instrumental activities of daily living
* Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \> 90 mmHg at rest
* Static visual acuity with correction of worse than 1.0 logMAR
* Manifest ocular misalignment ≥ 5 diopters (e.g., tropia, lazy eye, strabismus}
* Convergence insufficiency
* Intra-nuclear ophthalmoplegia
* Vestibular Migraine
* Major orthopedic conditions that limit cervical spine range of motion or that alter walking
* Self-reported current or potential for pregnancy during enrollment
* Ongoing participation in vestibular rehabilitation for dizziness
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.