CompletedPhase 4

Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats

Egypt24 participantsStarted 2024-11-01

Plain-language summary

This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1 signalling pathway. The main questions it aims to answer are: 1. Is Lf administration 30 min. before or after RM induction in rats beneficial to kidneys and heart? 2. When administered to glycerol-induced rats, does Lf act by upregulating the AMPK/Nrf2/ HO-1 signalling pathway and inhibiting ferroptosis?

Who can participate

Age range10 Weeks – 12 Weeks

SexMALE

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Inclusion Criteria: * • Twenty-four healthy male Wistar Albino rats weighing from 250 to 300 g Exclusion Criteria: * No exclusion criteria as this study is used to detect effects of drugs on experimental rats.

What they're measuring

Nrf2 expression

Timeframe: 2 months

AMPK levels

Timeframe: 2 months

HO-1 levels

Timeframe: 2 months

Trial details

NCT IDNCT06491394

SponsorAswan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-01

View on ClinicalTrials.gov More Rhabdomyolysis trials