CompletedNot Applicable

Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure

Spain31 participantsStarted 2020-12-01

Plain-language summary

The aim of this prospective physiological cohort study conducted in a medical intensive care unit (ICU) at Hospital del Mar in Barcelona, Spain, was to analyze the proportion of time spent within the "safe" range of respiratory effort (including esophageal pressure swing (ΔPes), respiratory muscular pressure (Pmus), and transdiaphragmatic pressure swing (ΔPdi)) in patients with acute hypoxemic respiratory failure (AHRF) undergoing invasive mechanical ventilation (IMV), during the active breathing phase in relation to ICU survival. The investigators hypothesized that AHRF patients on IMV with better outcome (i.e., ICU survivors) spend more time within the "safe" range of respiratory effort during the active breathing phase compared to non-survivors. AHRF patients on IMV were continuously monitored with esophageal and gastric manometry from the detection of the onset of respiratory effort for up to 7 days, or until extubation, or until death, whichever occurred first.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Acute hypoxemic respiratory failure patients requiring invasive mechanical ventialtion Exclusion Criteria: * Presence of chest drains * Contraindication to esophageal catheterization (e.g., recent upper gastrointestinal surgery, bleeding esophageal varices) * Concomitant acute exacerbation of obstructive airways disease

What they're measuring

Proportion of time spent in different ranges of ΔPes (low, safe, and high) during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Proportion of time spent in different ranges of Pmus (low, safe, and high) during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Proportion of time spent in different ranges of ΔPdi (low, safe, and high) during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Median value of ΔPes during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Median value of Pmus during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Median value of ΔPdi during the active breathing phase between the two groups

Timeframe: From the start the start of respiratory effort up to 7 days (or until extubation or death, if earlier)

Trial details

NCT IDNCT06490523

SponsorHospital del Mar Research Institute (IMIM)

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-11-30

View on ClinicalTrials.gov More Acute Hypoxic Respiratory Failure trials