RecruitingNot Applicable

Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery

China568 participantsStarted 2025-07-28

Plain-language summary

Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD). Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function in patients with cognitive impairement. This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment.

Who can participate

Age range65 Years

SexALL

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Inclusion criteria

✓. Aged ≥65 years;
✓. Patients with preoperative mild to moderate cognitive impairment, defined as 9\<Montreal Cognitive Assessment (MoCA)\<26;
✓. Scheduled for elective non-cardiac surgery under general anesthesia, with an expected surgical duration of \>2 hours;
✓. Expected to stay in hospital for at least 5 days after surgery.

Exclusion criteria

✕. Left-handed;
✕. Primary school education level or below;
✕. Comorbid diseases including mental illness, intellectual disability, auditory and visual dysfunction, language impairment, severe neurological disorders, or other diseases that impede the completion of evaluation;
✕. Neurosurgery;
✕. Presence of contraindications to rTMS treatment, including epilepsy, pregnant or lactating women, or with a metal or electric implanted device (e.g., deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, pacemaker, cochlear implant, or surgical staples on the scalp);
✕. Other situations that are deemed unsuitable for inclusion in the study.

What they're measuring

Incidence of delayed neurocognitive recovery

Timeframe: On the 5th day after surgery

Trial details

NCT IDNCT06482749

SponsorPeking University First Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-08

Contact for this trial

Dong-Xin Wang, MD, PhD

8610 83572784 wangdongxin@hotmail.com

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