RecruitingNot Applicable

Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation

Belgium, Germany240 participantsStarted 2024-01-24

Plain-language summary

Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10 * Control group: No OD (TDI-score \>30.5.) Exclusion Criteria: * Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations * Use of anticoagulation therapy * Allergy to local anesthetics

What they're measuring

Analysis of olfactory cleft biopsies

Timeframe: From enrollment of 1 patient until analyzed, 1 month

Analysis of olfactory cytobrushes

Timeframe: From enrollment of 1 patient until analyzed, 1 month

Trial details

NCT IDNCT06482138

SponsorUniversitaire Ziekenhuizen KU Leuven

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Contact for this trial

Laura van Gerven

+3216336342 laura.vangerven@uzleuven.be

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