Based on available evidence and given the potential beneficial effects of resveratrol in folliculogenesis and in oocyte development, the investigators designed a randomized, controlled, double-blind, single-center trial, whose objective will be the comparison of biological and clinical outcomes of resveratrol supplement in women undergoing IVF/ICSI cycles for unexplained infertility. To the knowledge of the investigators, no study has been published on the potential effect of resveratrol on IVF/ICSI outcomes considering couples with this infertility diagnosis, which may be the natural target of this integrative treatment because the process of folliculogenesis and oocyte maturation cannot be routinely investigated. An alteration of these biological mechanisms could be the unrecognized cause of part of the unexplained infertility and treatment with resveratrol could result in significant clinical improvement for the patients enrolled in the study. In more details, the main objective of this randomized, placebo-controlled, double-blind, single-center trial will be the evaluation of the possible effect of resveratrol in determining a better follicle development in patients with unexplained infertility undergoing controlled ovarian stimulation (COS) for IVF/ICSI. Infertile female patients with normal ovarian reserve will be treated according to clinical practice and the difference between expected (through AFC) and retrieved oocytes will be assessed in relation to use of resveratrol.
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FORT (Follicle Output Rate)
Timeframe: The assessment will be performed at the end of stimulation (11°-15° day of a menstrual cycle of 28 days)
FOI (Follicle to Oocyte Index)
Timeframe: The assessment will be performed at the end of oocyte pick up (2 hours after the oocyte pick up)
The number of mature oocytes
Timeframe: The assessment will be performed after the oocyte pick up (2 hours after the oocyte pick up)
OSI (Ovarian Sensitivity Index)
Timeframe: The assessment will be performed at the end of oocyte pick up (2 hours after the oocyte pick up)