CompletedNot Applicable

Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis and Staging of Lung Malignancies

Egypt40 participantsStarted 2021-12-21

Plain-language summary

Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis. Fludeoxyglucose-18 (FDG) positron emission tomography (PET) combined with low dose contrast computed tomography (CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are two diagnostic modalities widely used in the field of staging \& diagnosis of lung malignancies, the former depends on image analysis while the later enables real-time sampling of lymph nodes under sonographic guidance with concurrent cytological examination. The present research aims to compare the diagnostic and staging accuracies of (EBUS-TBNA) versus FDG-PET /CT as two diagnostic modalities in patients with suspected lung malignancies. However as a secondary outcome this study aims at monitoring the possible complications arising post EBUS-TBNA procedure.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * Patients 18 years old or more. * Patients presented with centrally located suspiciously malignant lung masses with or without lymphadenopathy. * patients with mediastinal lymphadenopathy only as evident by contrast - enhanced CT scan of the chest. * patients with peripheral lung malignancy and mediastinal lymphadenopathy who were referred for MLN staging were also recruited to the research Exclusion Criteria: * All patients who were who were unfit for bronchoscopy as per international guidelines for practice. * Cases are diagnosed with stage IV (metastatic) lung cancer. * Patients with histopathological diagnosis other than malignancy (as Sarcoidosis, Tuberculosis). * patients unfit for FDG-PET G-PET/CT examination (uncontrolled Hyperglycemia, renal impairment). * Patients who refused to participate to the study.

What they're measuring

Comparing the diagnostic accuracies of both EBUS TBNA and FDG-PET /CT

Timeframe: 2 years

Comparing the staging accuracies of both convex probe EBUS-TBNA versus FDG - PET/CT

Timeframe: 2 years

Trial details

NCT IDNCT06479798

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-01