SuspendedNot Applicable

Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer

Stopped: Administrative reasons.

United States100 participantsStarted 2026-05

Plain-language summary

The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in patients with metastatic head and neck squamous cell carcinomas.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinically confirmed node positive head and neck squamous cell cancer * Written informed consent signed and dated by the patient prior to the performance of the MSOT * At least 18 years-of-age at the time of signature of the informed consent form (ICF) * Patients planned for curative intent therapy * Patient available for the study duration * Patients of childbearing potential must have a negative pregnancy test prior to the study entry. * Patients of childbearing potential must use an effective form of contraceptive as per the protocol. Exclusion Criteria: * History of previous head and neck radiotherapy * Intent of treatment palliative * Women who are pregnant * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety of efficacy assessment of the investigational regimen should be included. * Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol and/or follow-up procedures outlined in the protocol.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Adverse events due to MSOT imaging prior to surgery

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging prior to radiotherapy

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging during week 4 of radiotherapy

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging after the completion of radiotherapy treatment.

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Measurement of skin temperature before MSOT imaging

Timeframe: 1-2 minutes before the MSOT image.

Measurement of skin temperature after MSOT imaging

Timeframe: 1-2 minutes after the MSOT image

Trial details

NCT IDNCT06477003

SponsorUniversity of Oklahoma

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11

View on ClinicalTrials.gov More Head and Neck Squamous Cell Carcinoma trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Adverse events due to MSOT imaging prior to surgery

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging prior to radiotherapy

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging during week 4 of radiotherapy

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Adverse events due to MSOT imaging after the completion of radiotherapy treatment.

Timeframe: 30 minutes for an MSOT image (up to 24 hours post-image)

Measurement of skin temperature before MSOT imaging

Timeframe: 1-2 minutes before the MSOT image.

Measurement of skin temperature after MSOT imaging

Timeframe: 1-2 minutes after the MSOT image