Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac S… (NCT06474754) | Clinical Trial Compass
RecruitingNot Applicable
Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery
United States61 participantsStarted 2025-03-30
Plain-language summary
The goal of this clinical trial is to learn whether physicians can associate evidence of myocardial injury after surgery with findings obtained from submaximal cardiopulmonary exercise testing. The main questions are:
Is detection of postoperative myocardial injury with submaximal cardiopulmonary exercise testing superior to using usual care?
And which submaximal cardiopulmonary exercise testing measure is better?
Participants will undergo evaluation with a short submaximal cardiopulmonary exercise test, then undergo surgery. Myocardial injury will be measured on postoperative days 0, 1, 2, and 3 (during and up to 3 days after surgery). These results will analyzed by comparing it to findings from the submaximal cardiopulmonary exercise test.
If there is a relationship, this will help anesthesiologists and surgeons assign certain treatments that may reduce the risk of developing myocardial injury after surgery.
Who can participate
Age range45 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Provision of signed and dated informed consent form.
✓. Stated willingness to comply with all study procedures and availability for the duration of the study.
✓. Biological male or female, aged 45 years or older.
✓. In good general health as evidenced by medical history or diagnosed with metabolic equivalents (self-reported ability to climb 1 flight of stairs).
✓. Revised Cardiac Risk Index less than or equal to three.
✓. Willing to accept phlebotomy on operative day 0, 1, 2, and 3, as part of usual care.
✓. Scheduled for moderate to high-risk elective non-cardiac surgery with an expected 24-72 hour stay within 60 days of enrollment in the study.
Exclusion criteria
✕. Inability to perform study procedures as defined by inability to achieve greater than 4 metabolic equivalents (cannot climb 1 flight of stairs reliably).
✕. Pregnancy or lactation.
What they're measuring
1
MINS
Timeframe: Operative Day 0, Postoperative Day 1, 2 or 3