MYCobiome Analysis in Atopic Dermatitis With Head and Neck Involvement

Inclusion Criteria: * Age between 18 and 65 years; * Male or female; * The diagnosis of atopic dermatitis (AD) is defined according to the criteria of UK Working Party with at least 3 of the following 5 criteria are present; history of flexural involvement, history of a dry skin, onset under the age of 2, personal history of asthma or allergic rhinitis, history of a pruritic skin condition, and visible flexural dermatitis. * Generalized AD defined by AD involved ≥50% of total body surface area with head and neck involvement. Or HNAD defined by AD involving at least 80% of the head and neck area with or without AD involvement outside the head and neck area but \<20% of total body surface area. * With or without topical anti-inflammatory treatments for AD (including; topical steroids and/or topical tacrolimus) * Free, informed and written consent, signed by the patient and the investigator before any examination required by the trial; * Affiliation to social security scheme (beneficiary or assignee) * Healthy control are the same age and sex. Exclusion Criteria: * Systemic or local antifungal therapy within 2 months before entry and during the study * Systemic treatments for AD; including: ciclosporine, dupilumab and others AD biologics, methotrexate, JAK-inhibitors * Current participation in another interventional research * Patient with a measure of legal protection * Psychiatric illness or any other concomitant chronic illness or addiction that could be interfere with the…