Optic neuritis (ON) represents around 30% of clinical presentation of clinically isolated syndrome (CIS). Asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (MS) disease including the CIS. However, optic nerve is still not part of MS diagnosis criteria. The main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve involvement at the earliest clinical stage of MS (=CIS) for the diagnosis of clinically definite MS (2nd clinical relapse) and the delay until the 2nd relapse.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Optic nerve involvement defined by occurrence of a recent clinical episode of ON
Timeframe: assessed at baseline
Asymptomatic optic nerve involvement defined by MRI (detection of an optic nerve T2 hypersignal)
Timeframe: assessed at baseline
Risk of a new clinical relapse will be assessed by the occurrence and time to onset of a second MS clinical relapse
Timeframe: assessed every 6 months during 24 months
Asymptomatic optic nerve involvement defined by OCT (GCIPL-IETD,3pm)
Timeframe: assessed at baseline
Risk of a new clinical relapse will be assessed by the occurrence and time to onset of a CDMS
Timeframe: assessed every 6 months during 24 months