Pharmacokinetics, Safety and Tolerability of Clascoterone Cream 1% in Healthy Chinese Adult Subjects

Inclusion Criteria: * Chinese adult subjects, male or female; * 18-45 years of age (18 years old and 45 years old are inclusive, on the day of signing the written informed consent); * Males should be ≥50.0 kg females should be ≥45.0 kg, respectively, and their body mass index \[BMI = weight (kg)/height2 (m2)\] should be within the range of 19.0 to 28.0 kg/m2 (including critical value); * Female subjects of childbearing potential or male subjects whose partners are of childbearing potential should agree and be able to use effective contraception from the time of signing the written informed consent to within 3 months after the last dosing (see Appendix 2 for details); * Subjects should be able to communicate well with the investigator and complete the study as per the protocol; subjects should be fully informed about the study and sign a written informed consent voluntarily. Exclusion Criteria: * Subject has a previous history of chronic or serious disease; * Subject who has undergone major surgical procedure or procedure affecting drug absorption, distribution, metabolism, or excretion within 6 months prior to screening, or plans to undergo surgery during the study; * Subject has a history of drug abuse and drug dependence; * Subject who has received any medication prior to screening; * Subject has previous allergies or has allergic symptoms; * Subject has skin damages; * Subject who has consumed alcohol regularly; * Subject has positive testing result of drug abuse and na…