Effects of PBMT-sMF in Mechanically Ventilated Patients

Inclusion Criteria: * Legally authorized representative signed informed consent; * Male or female aged 21 years or older; * On mechanical ventilation through orotracheal intubation for no more than 72 hours prior to study enrollment or pending mechanical ventilation through orotracheal intubation; * Predicted to remain on mechanical ventilation for at least 48 hours (≥48 hours) from the time of study enrollment Exclusion Criteria: * Mechanical ventilation initiated longer than 72 hours prior to anticipated enrollment; * Body Mass Index (BMI) \> 40 kg/m²; * Fever of 100.4°C or higher; * Situated in the prone position for 24 hours or longer during mechanical ventilation; * Prognosis of mortality within 72 hours, per the patient's physician; * Hypersensitivity to light; * Use of non-invasive ventilation, Continuous Positive Airway Pressure (CPAP) and/or Bilevel Positive Airway Pressure (BiPAP) device for ≥ 50% of the time over the preceding 6 months; * Tracheostomy; * Any one or more of the following present on both sides of the neck (bilaterally) at the intended treatment site(s): internal jugular (IJ) venous cannulation; incisions, significant bruising; burn(s); notable skin irritation/rash, or other skin condition that may place the subject at risk from harm from the device treatment; * Fracture, external or internal hemorrhage, or at risk of hemorrhage following acute trauma or fracture, or known or potential acute occult bleeding (e.g., gastric ulcer, intestine) in the i…