Not Yet RecruitingNot Applicable

The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

United States25 participantsStarted 2026-07-31

Plain-language summary

The purpose of the study is to see that in addition to existing therapy, how well an additional procedure named spinal cord stimulation might reduce blood vessel spasm from aneurysm rupture.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Provision of signed and dated informed consent form
✓. Stated willingness to comply with all study procedures and availability for the duration of the study
✓. Diagnosed with Fisher grade 3 or 4 aneurysmal subarachnoid hemorrhage (1)
✓. Ability to undergo endovascular treatment of aneurysmal subarachnoid hemorrhage
✓. For females of reproductive potential: Negative pregnancy test at time of treatment
✓. Plan to undergo standard of care and follow-up

Exclusion criteria

✕. Medically unfit to undergo endovascular treatment (e.g., Hunt Hess grade 5)
✕. Does not provide consent for the procedure.
✕. Posterior circulation aneurysmal subarachnoid hemorrhage.
✕. Initial aneurysm treatment after post bleed day 1

What they're measuring

Pre-Cerebrovascular response - Velocity

Timeframe: Day 1 - Day 14

Pre-Cerebrovascular response - Resistance

Timeframe: Day 1 - Day 14

Pre-Cerebrovascular response - Lindegaard ratio

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Velocity

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Resistance

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Lindegaard ratio

Timeframe: Day 1 - Day 14

Transcranial Doppler (TCD) velocities of cerebral arteries

Timeframe: Day 1 - Day 14

Trial details

NCT IDNCT06443177

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03-31

Contact for this trial

Jesse Jones, MD

205-934-7170 jessejones@uabmc.edu

View on ClinicalTrials.gov More Vasospasm, Cerebral trials

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Provision of signed and dated informed consent form
✓. Stated willingness to comply with all study procedures and availability for the duration of the study
✓. Diagnosed with Fisher grade 3 or 4 aneurysmal subarachnoid hemorrhage (1)
✓. Ability to undergo endovascular treatment of aneurysmal subarachnoid hemorrhage
✓. For females of reproductive potential: Negative pregnancy test at time of treatment
✓. Plan to undergo standard of care and follow-up

Exclusion criteria

✕. Medically unfit to undergo endovascular treatment (e.g., Hunt Hess grade 5)
✕. Does not provide consent for the procedure.
✕. Posterior circulation aneurysmal subarachnoid hemorrhage.
✕. Initial aneurysm treatment after post bleed day 1

What they're measuring

Pre-Cerebrovascular response - Velocity

Timeframe: Day 1 - Day 14

Pre-Cerebrovascular response - Resistance

Timeframe: Day 1 - Day 14

Pre-Cerebrovascular response - Lindegaard ratio

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Velocity

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Resistance

Timeframe: Day 1 - Day 14

Post-Cerebrovascular response - Lindegaard ratio

Timeframe: Day 1 - Day 14

Transcranial Doppler (TCD) velocities of cerebral arteries

Timeframe: Day 1 - Day 14