CompletedNot Applicable

Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome

Egypt20 participantsStarted 2020-05-12

Plain-language summary

It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached. The goal was to examine the effects of 6 months of home AVAPS therapy in patients with obesity hypoventilation syndrome as a potential option for patients who failed CPAP titration due to persistent hypoxemia.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All Clinically stable OHS patients with * Body mass index of 30 kg/m2 , * Daytime hypercapnia (PaCO2 \>45 mm Hg) who had failed to respond to CPAP therapy * had no other cause for their chronic respiratory failure and were naive to any PAP therapy. Exclusion Criteria: * Patients with evidence of acute respiratory failure (patients with worsening symptoms during the last 2 weeks before the screening visit, a breathing frequency of 30 breaths/ minute, or signs of respiratory infections) * Patients who had been intubated during the last 3 months * Patients who had received any other form of ventilatory support before hospital admission were also excluded from the study

What they're measuring

To compare the initial diagnostic, and therapeutic sleep study parameters using either CPAP and (AVAPS-AE) titration study in patients with OHS.

Timeframe: 1 week

Trial details

NCT IDNCT06442163

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-30

View on ClinicalTrials.gov More Obesity Hypoventilation Syndrome (OHS) trials