CompletedNot Applicable

More Than 50% of Unifocal cN0 T1b/Small T2 Papillary Thyroid Carcinoma May Require Completion Thyroidectomy if Nodal Status is Evaluated

314 participantsStarted 2014-09-01

Plain-language summary

In absence of nodal metastases or aggressive features, thyroid lobectomy (TL) should be preferred over total thyroidectomy (TT) for small unifocal papillary thyroid carcinoma (PTC). However, occult, despite non-microscopic (\>2 mm), nodal metastases may be present in clinically node-negative (cN0) PTCs. Among 4216 thyroidectomies for malignancy (2014-2023), 110 (2.6%) TL plus ipsilateral central neck dissection (I-CND) were scheduled for unifocal cT1b/small cT2 (\<3 cm) cN0 PTCs. Nodes frozen section examination (FSE) was performed: when positive, completion thyroidectomy (CT) was accomplished during the same procedure. In presence of aggressive pathologic features, CT was suggested within 6 months from index operation.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age\>18 * classic papillary carcinoma and variants * clinically unifocal and intrathyroidal PTC * clinical tumor size \>1 cm and ≤3 cm * no clinical evidence of LN involvement Exclusion Criteria: * age \< 18 * prior head or neck irradiation * family history of thyroid carcinoma * clinical evidence of multifocality * extrathyroidal extension or LN metastases * follow-up \< 6 months.

What they're measuring

evaluation of patients requiring total thyroidectomy

Timeframe: September 2014-September 2023

Trial details

NCT IDNCT06439745

SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-09-01

View on ClinicalTrials.gov More Papillary Thyroid Cancer trials