The Fulness Trial (Fundus mUcosaL abLation aNd Endoscopic Sleeve Gastroplasty)

Inclusion Criteria: * 1\. Male or females patients in the range of class Class I to Class II obesity (30 ≤ BMI ≤ 39.9). * Age between 18 and 65 years (both inclusive). * Treatment naïve for bariatric surgery or endoscopic bariatric therapy. * Patients that have been evaluated by the local MDT and have indication to ESG. * Willingness to comply with the substantial behavioral modifications program as required by the procedure. * Agree to avoid any use of weight loss medications such as Meridia, Saxenda, Januvia, Xenical, or over the counter weight loss medications or supplements throughout the study. * Women of childbearing potential should have negative urine beta human chorionic gonadotropin (hCG) pregnancy test and must agree to use acceptable contraception methods throughout the study duration. * Able to comply with study requirements and understand and sign the Informed Consent Form. Exclusion Criteria: * Previous upper GI surgery (except uncomplicated cholecystectomy or appendectomy), or other endoscopic bariatric procedures or conditions, * Prior intra-gastric balloon or another gastric implant. * History of a structural or functional disorder of the esophagus or pharynx that may impede passage of the device such as achalasia, stricture/stenosis, esophageal varices, esophageal diverticula, esophageal perforation, severe or intractable gastro-esophageal reflux symptoms while on maximal medical therapy, uncontrolled GERD defined as LA grade C esophagitis or greater. * …