Active — Not RecruitingNot Applicable

Prophylactic Antibiotics in Endoscopic Secondary Prevention of Gastroesophageal Variceal Bleeding

China226 participantsStarted 2024-05-25

Plain-language summary

Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this non-inferiority trial, we are aimed to evaluate whether prophylactic antibiotics are essential in the endoscopic secondary prevention of cirrhotic patients with gastroesophageal variceal bleeding.

Who can participate

Age range18 Years – 80 Years

SexALL

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Exclusion criteria

✕. Age \<18, or ≥81.
✕. The patient is unwilling to sign the informed consent form.
✕. Allergy to cephalosporin.
✕. Have granulocyte deficiency (neutrophil count ≤ 0.5 \* 10 \^ 9/L, or white blood cell count ≤ 1.0 \* 10 \^ 9/L) before the endoscopic operation.
✕. Already have infection or fever (body temperature \> 37.5 ℃) before signing the informed consent form.
✕. The patient turned back after signing the consent, and before the endoscopic operation.
✕. Have fever (body temperature \> 37.5 ℃) after signing the consent, and before the endoscopic operation.
✕. Transferred to other department for additional treatment after the endoscopic operation (Surgical department for malignant tumor, Interventional radiology department for splenic embolism or transjugular intrahepatic portosystemic shunt, etc.).

What they're measuring

Postoperative fever

Timeframe: From the date of endoscopic operation (after the endoscopy) until the date of hospital discharge, assessed up to 7 days.

Trial details

NCT IDNCT06437964

SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-15

View on ClinicalTrials.gov More Cirrhosis, Liver trials