RecruitingNot Applicable

Electrical Phrenic Nerve Stimulation in Patients With VIDD

China40 participantsStarted 2024-06-04

Plain-language summary

This study aims to examine efficacy of transcutaneous electrical phrenic nerve stimulation (TEPNS) in ventilator-induced diaphragmatic dysfunction (VIDD). The investigators recruit VIDD patients, and randomly assign the patients into TEPNS group and control group. TEPNS group receives TEPNS twice a day for consecutive 5 days. Control group only receives usual care. The investigators collect diaphragm function indicators and outcomes to evaluate the efficacy.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * aged ≥ 18 years * ventilated for at least 48 h with an expected stay of more than 7 days in the ICU * diaphragm thickening fraction (DTF)\< 25% Exclusion Criteria: * having a pacemaker * cutaneous lesion that could interfere with probes * previous diaphragmatic nerve paralysis * body mass index \> 35 kg/m2 * severe chronic obstructive pulmonary disease (FEV1/FVC\<30%) * pregnancy or lactation * decision to withhold life-sustaining treatment

What they're measuring

Transdiaphragmatic pressure (Pdi)

Timeframe: Collected once a day after transcutaneous electrical phrenic nerve stimulation (TEPNS) for consecutive 5 days

Trial details

NCT IDNCT06436950

SponsorPeking University Third Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12

Contact for this trial

Zongyu Wang, Dr.

008601082267028 wangzy1976@126.com

View on ClinicalTrials.gov More Diaphragms trials