The Association Between Respiratory Effort Parameters During the First 48 Hours With Clinical Out… (NCT06433076) | Clinical Trial Compass
CompletedNot Applicable
The Association Between Respiratory Effort Parameters During the First 48 Hours With Clinical Outcomes in Mechanically Ventilated Patients: A Prospective Observational Study.
Thailand163 participantsStarted 2022-06-08
Plain-language summary
Over-assisted mechanical ventilation (MV) is linked to respiratory muscle disuse atrophy, while under-assisted MV can lead to patient self-inflicted lung injury (P-SILI) or respiratory muscle injuries. Both scenarios result in poor outcomes. This hypothesis aims to demonstrate the association between the degree of respiratory effort which was measured by P0.1, predicted Pmus, and predicted Δtranspulmonary pressure (ΔPL) with ventilator-free days (VFD) and 28-day mortality.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Participants must be aged between 18-75 years.
✓. Admitted to the critical care and semi-critical care units (ICUs) of the Department of -Internal Medicine, Ramathibodi Hospital (ICUs 9IC, 8IK, and 7NW).
✓. Patients with acute respiratory failure admitted to the hospital with the following conditions within the first 48 hours:
✓. Permission obtained from the attending physician.
✓. Research participants or their direct relatives must sign informed consent.
✓. The research can commence and data can be recorded within 48 hours after the patient has received treatment with the mechanical ventilator.
Exclusion criteria
✕. Admitted to the hospital or had a history of hospital admission within a month before recruitment.
✕. History of cardiovascular or cerebrovascular events within the last 12 months.
✕. Pregnant.
What they're measuring
1
28 days ventilator-free days (VFDs)
Timeframe: After intubated patients were recruited until successful extubation or dead/failed extubation with in 28 days.