Active — Not RecruitingNot Applicable

Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii

France300 participantsStarted 2024-06-01

Plain-language summary

The main objective of the proposed research is to identify Pneumocystis jirovecii mutant strains on 4 genes encoding therapeutic targets such as dihydropteroate synthase (DHPS), dihydrofolate reductase (DHFR), cytochrome b (CYB), inosine-5'-monophosphate dehydrogenase (IMPDH) and therefore to assess the prevalence of potentially resistant strains in patients infected with P. jirovecii.

Who can participate

SexALL

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Inclusion Criteria: * Patients in whom P. jirovecii was detected in a pulmonary sample (bronchoalveolar lavage, sputum, bronchial aspiration, oropharyngeal rinse, nasopharyngeal sample) * No opposition * Patient affiliated to a social security system Exclusion Criteria: * Patients under legal protection (guardianship, curatorship) * Refusal to participate

What they're measuring

Presence of specific strains of Pneumocystis jirovecii potentially resistant to treatments in patients infected with this fungus

Timeframe: at inclusion

Trial details

NCT IDNCT06431958

SponsorUniversity Hospital, Brest

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

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