RecruitingNot Applicable

Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability

China40 participantsStarted 2024-06-08

Plain-language summary

This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. age ≥18 years
✓. Moderate-to-severe ARDS as per the 2023 ESICM definition
✓. Undergoing invasive mechanical ventilation
✓. Planned prone position based on the attending physicians' decisions
✓. Signed informed consent

Exclusion criteria

✕. age ≥85 years
✕. Pregnancy
✕. Severe hemodynamic instability (\> 30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min)
✕. Clinically suspected elevated intracranial pressure (\>18 mm Hg)
✕. Bronchopleural fistula
✕. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
✕. Severe hypernatremia (\>170mmol/L)
✕. Re-admission of patients already enrolled in this study, or patients who are participating in other studies

What they're measuring

Ventilation-perfusion matching (V/Q match%)

Timeframe: Through study completion (within 24 hours)

Trial details

NCT IDNCT06430554

SponsorZhongda Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06-30

Contact for this trial

Fengmei Guo, PhD, MD

+8613813841261 fmguo2022@163.com

View on ClinicalTrials.gov More Respiratory Distress Syndrome trials