Efficacy of Non-surgical and Surgical Surface Decontamination Methods on Peri-implantitis-affected Implants

Inclusion criteria: * Adult individuals between 18 and 80 years of age who require the explantation of at least one titanium or titanium alloy implant due to severe peri-implantitis (\> 50% bone loss and signs of inflammation); * Individuals who did not undergo surgical or non-surgical peri-implant therapy in the previous 6 months. Exclusion criteria: * Acute infection associated with adjacent teeth; * Any technical complication that does not allow implant removal using a reverse torque device; * Active infectious diseases of any kind; * Medical conditions which requires premedication prior to dental treatments/visits; * Pregnant women or planning to become pregnant (self-reported); * History of radiotherapy in the head and neck or chemotherapy in the last 3 years; * Any other diseases or medications that may contraindicate the surgical procedure or compromise wound healing.