Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF)

Inclusion Criteria: * Age 30-80 years old * Degenerative spine problems including spinal stenosis, disc degeneration, spondylolithesis that indicated for single level MI-TLIF Exclusion Criteria: * Revision surgery * Patients who had high risk of complication from TXA * History of seizure, PE, DVT, thromboembolic episode * History of TXA allergy * Patients who had high risk for bleeding * U/D : CKD stage more than IIIb (GFR\< 45 ml/min/1.73m2), hepatic disease, bleeding disorder * On anticoagulation drug or antiplatelet drug in 7 days before surgery * Abnormal coagulation profile (INR \> 1.5) or CBC (platelet \< 100000)