Active — Not RecruitingNot Applicable

PTLD: Multicentric Retrospective Study

Italy241 participantsStarted 2024-10-30

Plain-language summary

This is a multicentric observational retrospective cohort study of patients with histological diagnosis of PTLD. The aim of the study is to analyze the clinical features and survival of patients who received a PTLD diagnosis with the target to assess a survival outcome, to obtain an epidemiologic and clinical characterization of the subpopulations affected by PTLD, to recognize unfavorable properties, to report the current treatment strategies, to provide rationale for the design of a prospective registry in order to develop future novel treatments.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * histological diagnosis of PTLD obtained from a biopsy sample (availability of stocked biopsy sample is requested but not mandatory); * age over 18 years at time of diagnosis of PTLD; * previously subjected to allogeneic transplantation (both SOT and HSCT); * diagnosis of PTLD obtained in 10 years' time frame (from 01/01/2011 to 31/12/2021); * free and voluntary written informed consent (included unreachable subjects according to Art. 36 UE Regulation 2016/679 and to the current Italian Privacy Regulation). Exclusion Criteria: * Patients not meeting the above-mentioned inclusion criteria.

What they're measuring

Rate of Overall Survival

Timeframe: from diagnosis of PTLD to patient's death / last FUP - up to 18 months.

clinical and epidemiological features

Timeframe: from diagnosis of PTLD to patient's death/ last FUP - up to 18 months.

Trial details

NCT IDNCT06422715

SponsorFondazione Italiana Linfomi - ETS

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-08-12

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