Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery (NCT06421688) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery
China86 participantsStarted 2024-06-01
Plain-language summary
The goal of this clinical trial is to investigate the effect of perioperative administration of vitamin C on postoperative pulmonary complications, with the aim of providing a safe and effective medication regimen for the prevention and treatment of postoperative pulmonary complications in patients undergoing surgery for craniocerebral tumors. The main questions it aims to answer are:
1. To determine whether vitamin C can reduce pulmonary complications after surgery for intracranial tumors.
2. Does intraoperative vitamin C improve the prognosis of surgical patients
Researchers will compare vitamin C to a placebo (saline) to see if vitamin C is effective for postoperative lung complications in patients undergoing surgery for cranial tumors.
1. Participants will be intravenously pumped with vitamin C for two hours after induction of anesthesia.
2. Participants will have intraoperative plasma sampling and recording of ventilator parameters, monitor parameters and perioperative data.
3. Participants will be followed up until discharge from the hospital to record symptoms and adverse events, and will be called at six months to check on their prognosis.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Patients who need craniotomy treatment due to intracranial tumors;
✓. age 18-75 years old;
✓. American Society of Anesthesiologists classification: 1\~3;
✓. Patients and their families agree to participate in the study and sign the informed consent form.
Exclusion criteria
✕. Patients with severe pulmonary infection or respiratory failure prior to surgery;
✕. Patients with previous history of neurological or psychiatric diseases;
✕. Patients with cardiac, hepatic and renal insufficiency;
✕. patients who are receiving parenteral nutrition;
✕. pregnant patients;
✕. Patients ruled out by medication instructions;
✕
What they're measuring
1
incidence of postoperative pulmonary complications