UnknownNot Applicable

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

274 participantsStarted 2024-05

Plain-language summary

The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with inflammation/pain. Moreover, the following alternative targets are: VEGF, PAX6 and pro-inflammatory cytokine. The following procedures are performed specifically for the study: samples of blood, tear fluid and impression cytology. Precisely during the ophthalmological exam performed according to normal clinical practice (uncorrected visual acuity, best spectacle corrected visual acuity, corneal topography, corneal pachymetry and the slit lamp pictures) investigator's team collect the samples of blood, tear fluid and impression cytology to evaluate the goal of the study.

Who can participate

Age range18 Years – 99 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion Criteria for study group * Women and men with age equal or higher than 18 years (patients in reproductive age may be included in the study). * Willingness and ability to read and understand the informed consent. * Diagnosis (including genotype, if needed) of REDs. Inclusion Criteria for control group * Women and men with age equal or higher than 18 years (patients in reproductive age may be included in the study). * Willingness and ability to read and understand the informed consent. * Non - diagnosis of REDs. Exclusion Criteria: Exclusion Criteria for study group Patients who meet these criteria will be excluded from participation in the study: * Pregnancy, breastfeeding. * Active ocular infection. * Descemetocele/impending corneal perforation. * Recent (less than 3 months) ocular surgery. * Recent (less than 1 month) change in topical medications type and frequency. Exclusion Criteria for control group Patients who meet these criteria will be excluded from participation in the study: * Pregnancy, breastfeeding. * Active ocular infection. * Descemetocele/impending corneal perforation. * Recent (less than 3 months) ocular surgery. * Recent (less than 1 month) change in topical medications type and frequency.

What they're measuring

To quantify the expression of molecular/cellular/genomic targets in the REDs and control group to detect statistically significant and clinically relevant differences.

Timeframe: Day 0 (enrollment day).

Trial details

NCT IDNCT06412718

SponsorIRCCS Ospedale San Raffaele

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-04