Vit D and Post-extractive Bone Turnover

Inclusion Criteria: * Male or female adult (≥ 18 years old) * Patients willing to participate and to attend the planned follow-up visits Exclusion Criteria: * Absence of Type 1-Medical conditions requiring prolonged use of steroids and/or medications that can interfere with bone metabolism * History of leukocyte dysfunction and deficiencies * History of neoplastic disease requiring the use of radiation or chemotherapy * History of renal failure * Metabolic disorders such as osteoporosis and correlated vit D or antiresorptive medications assumption * Physical handicaps that would interfere with the ability to perform adequate oral hygiene * History of uncontrolled endocrine disorders * Alcoholism or any drug abuse * History of immunodeficiency syndromes * Smoker of 10 cig per day, cigar equivalents or tobacco chewers * Conditions or circumstances which in the opinion of the investigator would prevent completion of study participation or interfere with the analysis of the study results, such as history of non-compliance or unreliability * Mucosa disease such as erosive lichen planus * Residual post-extraction site with intact bone walls * History of local irradiation therapy * Persistent intraoral infection