CompletedNot Applicable

Significance of Benign Lymph Node Enlargement in Colorectal Cancer

2,270 participantsStarted 2015-01-01

Plain-language summary

The objective of this observational study was to investigate the clinical significance of benign mesenteric lymph node （BLNE） enlargement in patients with colorectal cancer. The main questions it aims to answer are: Do patients with benign mesenteric lymph node enlargement have a better prognosis? What are the clinical characteristics of benign mesenteric lymph node enlargement? As part of routine medical care for colorectal cancer, we will follow up with all participants over the course of the study.

Who can participate

SexALL

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Inclusion Criteria: * no regional lymph node metastasis or distant metastasis; * stage I and II patients in the AJCC staging system; * radical CRC resection achieving R0 status with no positive lymph nodes; * a single malignant lesion confirmed via colonoscopy Exclusion Criteria: * underwent emergency surgery or had preoperative complications such as intestinal obstruction or perforation; * had suspected distant metastasis on positron emission tomography (PET-CT); * received preoperative neoadjuvant therapy; * had hereditary CRC such as familial adenomatous polyposis; * had microsatellite instability (MSI) confirmed by pathology. * lacked imaging data; * were lost to follow-up.

What they're measuring

Disease-free survival of participants

Timeframe: The time from the participants' first postoperative day to their last follow-up.

Trial details

NCT IDNCT06410729

SponsorPeking University Third Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-06-30

View on ClinicalTrials.gov More Colorectal Neoplasms Malignant trials