CompletedPhase 4

Block and Periarticular Injection Study

United States174 participantsStarted 2024-03-04

Plain-language summary

The purpose of the study is to compare two types of perioperative analgesic modalities, adductor canal block plus interspace between popliteal artery and capsule of the knee (IPACK) block and periarticular injection versus periarticular injection alone, to determine their relative efficacies with regard to pain relief and functional outcomes in the early postoperative period following primary total knee arthroplasty.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Planning to undergo Unilateral primary total knee arthroplasty. * 18 and up * Willing to sign informed consent * Willing to return for all follow-up visits * Smartphone or tablet device capable of running the FocusMotion platform Exclusion Criteria: * BMI \> 45 * Preexisting functionally limiting neurologic disorders * Hepatic or renal insufficiency * History of unprovoked venous thromboembolism * Inability to complete baseline functional testing * Chronic opioid or gabapentin and pregabalin use (chronic defined as use \>5 days per week prior to the surgical procedure) * Allergy or intolerance to trial medications * Planned admission to a postoperative rehabilitation facility * Planned general anesthesia * Receiving workers compensation or disability payments

What they're measuring

Mean Visual Analog Scale (VAS) Pain Score for 2 Weeks Postoperatively

Timeframe: at 2 weeks

Trial details

NCT IDNCT06410612

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-12

Results submitted2026-02-20

View on ClinicalTrials.gov More Pain, Postoperative trials