CompletedNot Applicable

Impact of Topical Pentoxifylline and Tocopherol in Treatment and Prevention of Medically-related Osteonecrosis of the Jaws

Italy48 participantsStarted 2020-04-02

Plain-language summary

While there is no doubt about the benefits of antiresorptives, it is known that patients using these drugs are at increased risk of developing osteonecrosis of the jaws (MRNOJ), especially after oral procedures such as tooth extraction. The management of osteonecrosis has remained a controversial topic within the oral and maxillofacial surgery community. The aim of the present study is to analyze the impact of topical pentoxifilline and tocopherol in the prevention and treatment of MRNOJ.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Correspondence to the updated SIPMO criteria for MRONJ diagnosis * Need for tooth extraction Exclusion Criteria: * Recent use of antibiotics and anti-inflammatories in the last 4 weeks * Oral lesions of hard and soft tissues not related to MRONJ

What they're measuring

Oral Health Impact Profile Short Form (OHIP-14)

Timeframe: 6 months

Trial details

NCT IDNCT06409546

SponsorUniversity of Catania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-17

View on ClinicalTrials.gov More Medically Related Osteonecrosis of the Jaws trials