The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, the focus is on the content and function of Extracellular Vesicles (EVs), small sacs released from a cell's surface that contain important molecular cargo. The main questions it aims to answer are: 1. What molecular cargo do adipose-tissue EVs carry? 2. How do these cargo impact cardiac and hepatic function? 3. Are changes in EV content related to cardiac function and adiposity with weight loss? Tissue samples from fat tissue and blood samples will be collected from patients receiving bariatric weight loss surgery.
Age range
18 Years
Sex
ALL
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What are the contents inside of fat (adipose) tissue derived Extracellular Vesicles (EVs)?
Timeframe: 2 years
How does the contents of Extracellular Vesicles (EVs) impact cardiac and liver function?
Timeframe: 2 years
Are changes in Extracellular Vesicle (EV) content related to cardiac function and adiposity with weight loss?
Timeframe: 2 years