RecruitingNot Applicable

Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations

France20 participantsStarted 2024-11-05

Plain-language summary

Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes. Anomalies in ocular development , often of genetic origin, pose diagnostic and therapeutic challenges. Animal models are limited, so human-induced pluripotent stem cell (hiPSC)-derived optic vesicle containing brain organoids (OVBOs) offer a promising alternative. These pathological OVBOs, created from patients' cells with ocular malformations, allow for the study of underlying molecular mechanisms and testing of therapies.

Who can participate

Age range6 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Affiliated with a social security scheme. * Patients with ocular malformations. * Signed informed consent obtained from the patient and/or their legal representatives. Exclusion Criteria: * Inability to understand the nature and objectives of the study and/or difficulties in communicating with the investigator. * Deprivation of liberty by judicial or administrative decision. * Any other pathological or psychological condition deemed incompatible by the investigator for the proper conduct of the study.

What they're measuring

Culture of Optic Vesicles containing Brain Organoids (OVBOs) for the Study of Eye malformations

Timeframe: Day 60 of Development

Trial details

NCT IDNCT06408701

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2034-05-02

Contact for this trial

Julie Plaisancie, MD, PhD

0561779075 plaisancie.j@chu-toulouse.fr

View on ClinicalTrials.gov More Eye Abnormalities trials