CompletedNot Applicable

Intensive Aerobic and Resistance Exercise Program (IAREP)

Singapore58 participantsStarted 2023-07-21

Plain-language summary

A 12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention was implemented on high-risk and low-risk subjects with cognitive impairment in type 2 Diabetes Mellitus. The study aims to evaluate the effectiveness of IAREP on cognition, metabolic and inflammatory health, physical function, vascular health, and health practice behaviour in the Type 2 Diabetes Mellitus population (T2DM).

Who can participate

Age range

40 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 40 to 85 * Living in the community * Diagnosed with type 2 diabetes mellitus (T2DM) * Literate in English or Mandarin * Activities of daily living (ADL)-independent * Obtain at least a score of 5 in short physical performance battery (SPPB) test Exclusion criteria: * Severe cognitive (e.g., dementia) or psychiatric disorders (e.g., schizophrenia or severe depression) * Severe hearing or vision impairments * Terminally ill medical conditions (e.g., end stage cancer), severe cardiovascular, respiratory (e.g., respiratory failure), or orthopedic conditions (e.g., freeze shoulder) * Absolute contraindications to aerobic exercise and resistance training programs (e.g., recent myocardial infarction or electrocardiography changes, complete heart block, acute congestive heart failure, unstable angina, uncontrolled hypertension) * Pregnant or breastfeeding women * Uncomfortable with video-recording of intervention sessions

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Cognitive Function Based on Risk Stratification Score (RSS)

Timeframe: Baseline and 12 weeks

Number of Participants With Change in Cognitive Function (Cognitive Impairment) Based on Vascular Dementia Battery (VDB)

Timeframe: Baseline and 12 weeks

Change in Cognitive Function Based on the Montreal Cognitive Assessment (MoCA)

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT06401733

SponsorNational University of Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-31

Results submitted2025-07-16

View on ClinicalTrials.gov More Type 2 Diabetes Mellitus trials

Plain-language summary

Who can participate

Age range

40 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Cognitive Function Based on Risk Stratification Score (RSS)

Timeframe: Baseline and 12 weeks

Number of Participants With Change in Cognitive Function (Cognitive Impairment) Based on Vascular Dementia Battery (VDB)

Timeframe: Baseline and 12 weeks

Change in Cognitive Function Based on the Montreal Cognitive Assessment (MoCA)

Timeframe: Baseline and 12 weeks