Onvansertib in Combination With Gemcitabine and Nab-paclitaxel for the Treatment of Patients With Locally-advanced, Unresectable, or Metastatic Pancreatic Ductal Adenocarcinoma

Inclusion Criteria: * Must provide written informed consent before any study-specific procedures or interventions are performed * Must be ≥ 18 years old at the time of informed consent * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Histologically or cytologically-proven adenocarcinoma of the exocrine pancreas with locally advanced or metastatic disease * Must not have received prior radiotherapy, surgery, chemotherapy or investigational therapy for the treatment of metastatic disease. Prior palliative radiotherapy of metastases for alleviation of pain is permitted provided that irradiated metastases are not target lesions * Patient must be eligible to receive GnP regimen for the treatment of their PDAC in accordance with institutional standards * Must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 * Must have at least one disease lesion that is amenable to biopsy procedures performed per institutional standards * Group 1 participant must agree to undergo two (2) research biopsies * Group 2 participants must agree to undergo three (3) research biopsies * Hemoglobin ≥ 8.0 g/dL * Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/L (\> 1500 per mm\^3) * Platelet count ≥ 100 x 10\^9/L (\> 100,000 per mm\^3); * Creatinine ≤ 1.5 x upper limit of normal (ULN), or measured or calculated creatinine clearance \> 50 mL/min/1.73 m\^2 (per Cockcroft-Gault equation) * Aspartate aminotransferase (AST)/alan…