Active — Not RecruitingNot Applicable

Surgical Prehabilitation on Autonomic Nervous System (TUNE)

Italy100 participantsStarted 2024-07-29

Plain-language summary

This study will be a multicenter interventional randomized trial evaluating the effect of a multimodal prehabilitation program on heart rate variability (HRV). In the same protocol the impact of HRV on hospital length of stay will be identified. One hundred patients aged 18 years or older scheduled for elective surgery will be eligible for enrolment, if they will not present any exclusion criteria. Patients will be randomized with a 1:1 allocation to receive either prehabilitation or standard of care.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients scheduled to undergo major thoracic surgery including lobectomy, bilobectomy, anatomical segmentectomy, and pneumonectomy with general anesthesia; * Patients ≥18 years of age at the time of randomization; * Patients who provide written informed consent to participate. Exclusion Criteria: * New York Heart Association classes 3-4; * End-stage organ dysfunction; * American Society of Anesthesiologists physical status classes 4-5; * Disabling orthopedic, neuromuscular, and psychiatric diseases; * Other medical conditions that preclude safe training. * Atrial fibrillation or other arrhythmia (e.g. bigeminy, trigeminy) that preclude heart rate variability analysis. * Unable to provide written informed consent to participate

What they're measuring

Impact of prehabilitation on heart rate variability

Timeframe: 30 days after prehabilitation

Trial details

NCT IDNCT06398301

SponsorUniversità Vita-Salute San Raffaele

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-19

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