A Study to Investigate the Analgesic Efficacy of Ibuprofen Alone and Ibuprofen Plus Hyoscine-n- Butyl Bromide in Reducing Pain of Outpatient Hysteroscopy

Inclusion Criteria: * female patients older than 18 years who signed informed consent; * patients who need an office hysteroscopy for their diagnosis or treatment. Those indications included postmenopausal endometrial thickening (over 4 mm), metrorrhagia, sonographic suspicion of endometrial polyps or myomas, Essure device insertion, and endometrial biopsy Exclusion Criteria: * women with a possible pregnancy, ongoing vaginal bleeding, lower genital tract infection, gestational trophoblastic disease, asthma, hepatitis, renal failure, lactation, previous cervical surgery, or oversensitivity to one of the agents or their elements; * patients suffering from neuropathic pain or other conditions that can impact on the perception of pain; * individuals who use antidepressant, anxiolytics or other drugs/supplements that may have an impact on the perception of pain; * contraindications to the use of ibuprofen and/or Hyoscine N-Butil Bromide .