Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of patients with MS in the United States, Europe and France, to stratify the chances of RIS developing into MS. Identifying early biomarkers to predict greater disease severity would have a significant impact, not only on RIS but also on the entire clinical spectrum of multiple sclerosis.
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Aim 1a : Association between Serum Neurofilament Light chain (sNfL) and RIS in all groups of patients
Timeframe: Week 0
Aim 1a : Association between Serum Neurofilament Light chain (sNfL) and RIS in all groups of patients
Timeframe: Week 96
Aim 1a : Association between Serum Glial Fibrillary Astrocytic Protein (sGFAP) and RIS in all groups of patients
Timeframe: Week 0
Aim 1a : Association between Serum Glial Fibrillary Astrocytic Protein (sGFAP) and RIS in all groups of patients
Timeframe: Week 96
Aim 1b: Association between Serum Neurofilament Light chain (sNfL) and RIS in placebo-treated patients
Timeframe: Week 0
Aim 1b: Association between Serum Neurofilament Light chain (sNfL) and RIS in placebo-treated patients
Timeframe: Week 96
Aim 1b : Association between Serum Glial Fibrillary Astrocytic Protein (sGFAP)and RIS in placebo-treated patients
Timeframe: Week 0
Aim 1b: Association between Serum Glial Fibrillary Astrocytic Protein (sGFAP)and RIS in placebo-treated patients
Timeframe: Week 96