Clinical Validation of an MCED Test in Symptomatic Populations (K-ACCELERATE)

Inclusion Criteria: * Male or Female, aged 18 years or above Participants are willing and able to give informed consent for participation in the study * Participants aged over 18 years * Individuals presenting symptoms associated witht breast, colorectal, gastric, liver and lung cancer (see below) and being referred for low resolution imaging tests including US breast, chest x-ray, colorectal endoscopy, gastroscopy, US abdomen or relevant diagnostic modalities. * Symptoms and Signs * Breast symptoms: Axillary lump/mass; Breast lump/mass; Breast pain; Nipple discharges; Breast skin change * Lung symptoms: Symptoms for more than 3 weeks: Dyspnea (shortness of breath); Chest pain; Cough that does not go away; Hemoptysis (coughing up blood) * Colorectal symptoms: Hematochezia (blood in the stool); Diarrhea ≥ 3 weeks; Constipation ≥ 3 weeks; Abdominal pain ≥ 3 weeks * Gastric symptoms: Epigastric pain ≥ 3 weeks; Hematemesis (vomiting blood) * Liver symptoms: Jaundice (yellowing of the skin and eyes); Right upper quadrant (RUQ) pain; Significant weight loss (≥10% of body weight in previous 6 months) * Consent to undertake high resolution imaging tests or biopsy upon receiving positive test results from either SPOT-MAS or low-resolution imaging tests Exclusion Criteria: * Having a history of invasive cancer diagnosed within the last 5 years * Having undergone treatment for invasive cancer within the last 5 years * Having a history of bone marrow transplant or whole blo…