RecruitingNot Applicable

Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis

Finland80 participantsStarted 2023-05-26

Plain-language summary

The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood. Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.

Who can participate

Age range2 Years – 5 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Eczema Area and Severity Index ≥ 2 Exclusion Criteria: * Eczema Area and Severity Index \< 2 * Immune deficiencies, i.e., antibody deficiency * Immunosuppressive systematic medications * A disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes) * Cancer diagnosis * Topical medication for the treatment of atopic dermatitis during the trial * Disability affecting the immune response (e.g. Down's syndrome) * Non-participation in the national vaccine program * Participation in another intervention or follow-up study

What they're measuring

Eczema Area and Severity Index (EASI)

Timeframe: Baseline, 2 month, 6 month

Trial details

NCT IDNCT06390696

SponsorNatural Resources Institute Finland

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2027-09-30

Contact for this trial

Sanna Hurtola

+358295322500 sanna.hurtola@luke.fi

View on ClinicalTrials.gov More Atopic Dermatitis trials