A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma

Inclusion Criteria: * All individuals included in the study need to have had an endoscopic evaluation at the time of blood sampling. * Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment. * Received standard pathological and endoscopic diagnosis and assessment for cohort assignment. Exclusion Criteria: * Lack of written informed consent. * Short segment Barrett's esophagus with no evidence of dysplasia * Ultra-short segment Barrett's esophagus with no evidence of dysplasia