UnknownNot Applicable

Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study

China320 participantsStarted 2023-09-01

Plain-language summary

Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques.

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age range from 18 to 90 years old;
✓. Patients who met the diagnostic criteria of the 2018 Chinese guidelines for the diagnosis and treatment of acute ischemic stroke;
✓. Sign the informed consent form, provide relevant medical history information and provide blood, urine and stool samples.

Exclusion criteria

✕. Serious systemic diseases including malignancies;
✕. Alanine aminotransferase or aspartate aminotransferase \>2 times the upper limit of normal value or severe liver disease;
✕. Creatinine \>1.5 times the upper limit of normal or severe nephropathy;
✕. A long-term history of drinking, drug taking and chemical poisoning. A long-term history of drinking refers to a history of more than 5 years, equivalent to alcohol \>40g/d for men and 20g/d for women, or a history of heavy drinking within 2 weeks, equivalent to alcohol \>80g/d;
✕. Those with previous history of intestinal tumor, irritable bowel syndrome or inflammatory bowel disease or diagnosed in Hospital;
✕. Unable to retain the required samples.
✕. Age range from 18 to 90 years old;
✕. Patients who met the depression related criteria in the Chinese classification and diagnostic criteria for mental disorders;

What they're measuring

The severity of neurological damage in stroke patients

Timeframe: The evaluation will be conducted on the second day after admission

The functional recovery outcomes after stroke

Timeframe: The evaluation will be conducted at 3 months after admission

The severity of symptoms in patients with depression

Timeframe: The evaluation will be conducted on the second day after admission

Trial details

NCT IDNCT06379464

SponsorZhujiang Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-30

Contact for this trial

Kaiyu XU

13590349187 1500810165@qq.com

View on ClinicalTrials.gov More Acute Ischaemic Stroke trials

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age range from 18 to 90 years old;
✓. Patients who met the diagnostic criteria of the 2018 Chinese guidelines for the diagnosis and treatment of acute ischemic stroke;
✓. Sign the informed consent form, provide relevant medical history information and provide blood, urine and stool samples.

Exclusion criteria

✕. Serious systemic diseases including malignancies;
✕. Alanine aminotransferase or aspartate aminotransferase \>2 times the upper limit of normal value or severe liver disease;
✕. Creatinine \>1.5 times the upper limit of normal or severe nephropathy;
✕. A long-term history of drinking, drug taking and chemical poisoning. A long-term history of drinking refers to a history of more than 5 years, equivalent to alcohol \>40g/d for men and 20g/d for women, or a history of heavy drinking within 2 weeks, equivalent to alcohol \>80g/d;
✕. Those with previous history of intestinal tumor, irritable bowel syndrome or inflammatory bowel disease or diagnosed in Hospital;
✕. Unable to retain the required samples.
✕. Age range from 18 to 90 years old;
✕. Patients who met the depression related criteria in the Chinese classification and diagnostic criteria for mental disorders;

What they're measuring

The severity of neurological damage in stroke patients

Timeframe: The evaluation will be conducted on the second day after admission

The functional recovery outcomes after stroke

Timeframe: The evaluation will be conducted at 3 months after admission

The severity of symptoms in patients with depression

Timeframe: The evaluation will be conducted on the second day after admission