PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study) (NCT06378268) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study)
Vietnam626 participantsStarted 2024-04-24
Plain-language summary
This non-inferiority randomized controlled trial will be conducted at My Duc Hospital, Ho Chi Minh City, Vietnam.
This study compares the effectiveness of Progestin-Primed Ovarian stimulation versus GnRH protocol for ovarian stimulation in IVF treatment. Participants will be randomly assigned in a 1:1 ratio to receive Progestins or GnRH antagonists.
Who can participate
Age range
18 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Woman aged 18-40
* BMI ≤ 25kg/m2
* AMH \> 1.2ng/mL or AFC \>5
* Having indication for IVF treatment
* Agree to have frozen embryo(s) transfer
* Not participating in any other clinical trials
* Provision of written informed consent to participate
Exclusion Criteria:
* Undergoing IVF cycle with other protocols: Down-regulation, mild stimulation, Random start
* Oocyte donation cycles
* Undergoing vitrified oocyte accumulation
* Oocyte cryopreservation
* Cycle with PGT (Preimplatation genetic testing)
* Women with PCOS
* Women allergy to dydrogesterone, rFSH, GnRH antagonist
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.